To solve the edges, first separate them so there are four different colors in each slice. To do that, use half-twists to move same-colored pairs of edges into the positions shown. Preferably the remaining edges in each slice do not match the color of the pair in the other slice, more about that here. After the setup has been made do Sequence 3C‑E2 to separate the same-color pairs into different slices (last move is R' instead of R to preserve corners for 4-color cube). Repeat this process until all edges are separated and then restore the corners with half-twists.

After the edges have been separated the cube can be solved using the 6‑Color Edge Sequences. There is one difference which is that at the end of a solve there may remain a single pair of edges that need to be swapped. In the following example the green & yellow edges on the front face (in the E slice) need to be swapped. To solve, use sequence 6C‑E2 with a setup where two opposite edges are the same color, this is done with two red edges on the right face (in the S slice) on the third move.

After the edges are solved the centers can be solved using the supercube sequences shown here.