To solve a single twisted edge as shown on the above 4-color hypercube (without using macro 4C-1TWE):

1. Push bottom cell into center
2. Do Sequence 4C-E3
3. F2 left cell
4. Push right cell into center
5. Do Sequence 4C-E3
6. F2 right cell
7. Push left cell into center
8. Do Sequence 4C-E3
9. Push right cell into center
10. Do Sequence 4C-E3

To make a single twisted edge (on solved hypercube):

1. Do Sequence 4C-E3
2. Push left cell into center
3. Do Sequence 4C-E3
4. Push right cell into center
5. F2 right cell
6. Do Sequence 4C-E3
7. Push left cell into center
8. F2 left cell
9. Do Sequence 4C-E3
10. Push top