The following shows a comparison of the 6-Color/8-Color Edge Sequences on the 3D and 4D cubes. The sequences are different but the setup configurations are the same so they are functionally equivalent as is the solution method so solve it the same way as the 3D cube. There is another set of these four sequences for the middle layer. The inner layer becomes the outer layer with 4D rotation so no additional sequences are needed for it.

The original sequences from the regular 3D cube swap groups of three as can be seen on the following image (Sequence 8C-E3o). These are useful because often more than half of the 12 cubies can be matched in a setup which means that doing the sequence will reduce the number of misplaced cubies. So for example if 10 of the 12 match then 8 will be fixed (10 fixed less 2 misplaced equals net of 8 fixed).

Another reason to use the original sequences is that they are shorter as shown in the following table.